GBMSDG October Meeting - Resolving the Organ-Dependent Secretome

Join us for the next Greater Boston Mass Spectrometry Discussion Group Event!

On October 21st, Dr. Amanda Smythers, from Harvard Medical School and the Dana-Farber Cancer Institute, will present on "Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication."

📍 Location: Waters Immerse, 301 Binney St, Suite 102, Cambridge, MA 02142
📅 Date: October 21st, 2025

GBMSDG events are a great opportunity to learn about new mass spectrometry applications and network with the local MS community.

Special thanks to EvoSep and Waters for sponsoring the food, beverages, and event space!

Title: Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication

Abstract: Exercise produces broad physiological benefits, yet the molecular messengers that coordinate these effects across organs remain poorly defined. To address this gap, we developed a novel mass spectrometry–based framework for high-resolution, quantitative analysis of organ-specific secretomes. This approach enables consistent detection and relative quantification of both soluble and vesicle-associated proteins released directly from individual tissues, allowing us to compare secretion patterns across organs and physiological states. Applying this framework to models of exercise and metabolic remodeling reveals striking tissue-specific signatures and dynamic shifts that point to coordinated inter-organ communication. Distinct changes in the secreted proteomes of muscle, adipose tissue, lung, and placenta highlight the complexity of systemic signaling networks and demonstrate the reproducibility and depth achievable with this workflow. By resolving extracellular proteomes consistently across diverse tissues, this method expands the reach of secretome proteomics and provides a powerful platform for studying inter-organ signaling in vivo.

Info: Presentation: Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication

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