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Follow Oxbow Eco-CenterThe Oxbow Eco-Center is an Environmental Learning Center and nature preserve encompassing 225 acres along the St. Lucie River and located at 5400 NE St. James Drive in Port St. Lucie. Managed by the Environmental Resources Department of St. Lucie County, Oxbow Eco-Center is a place to learn about and enjoy the outdoors. Education programs are offered for St. Lucie County resident families, and visitors of all ages. Guided Nature Programs offer a glimpse into the 11,000 acres of preserve land in the county.