# Event Details

- **Event Name**: BioScience Forum Presents: Precision CRISPR Therapies
- **Event Start and End Date**: Tue, 31 Mar, 2026 at 05:00 pm – Tue, 31 Mar, 2026 at 07:00 pm
- **Event Description**: Join us to hear Aarif Khakoo share how Scribe is applying CRISPR technology to find cardiometabolic therapies. More info at www.biosf.org.About this EventPrecision CRISPR Therapies: Targeting Cardiometabolic Pathways with In Vivo Genome EditingOptimizing potency, specificity, and deliverability is critical in the development of all therapeutics, and perhaps especially so for those leveraging CRISPR technology to deliver in vivo genetic and epigenetic modifications. Scribe has established an approach for doing so, called CRISPR by Design™, to optimize its internal portfolio focused on cardiometabolic diseases as well as corporate collaborations in neurological, neuromuscular, and sickle cell diseases.Using a novel, easy-to-deliver, and relatively safer starting point — CasX — the company has designed and engineered two platforms with the potential to become standard of care for genetic medicines: ELXR for epigenetic silencing of multiple genetic targets without cutting DNA, and XE for direct gene editing with no detectable off-target editing.The lead program STX-1150 utilizes the Epigenetic Long-Term X-Repressor (ELXR) as the first CRISPR epigenetic editor that potently and durably silences the liver PCSK9 gene and has been shown to lower low-density lipoprotein cholesterol (LDL-C) after therapeutic dosing of <1mg/kg in non-human primates. This approach could offer a more effective alternative to existing LDL-C lowering treatments, particularly for patients at high risk of atherosclerotic cardiovascular disease (ASCVD). In addition, the STX-1200 program uses the XE (X-Editor) based approach to directly target the Lipoprotein(a) gene and has demonstrated >90% knockdown of Lipoprotein(a) levels in preclinical models. The strategy for in vivo delivery has included both adeno-associated virus (AAV) and lipid nanoparticles (LNP).Dr. Khakoo will discuss the technical challenges and opportunities of the approaches utilized by Scribe across their pipeline, the latest preclinical data driving the programs forward, and steps being taken towards clinical evaluations.Agenda?: 05:00 PM - 06:00 PMNetworking, Appetizers and DrinksInfo: Network with local bioscience professionals while enjoying appetizers and drinks.?: 06:00 PM - 07:00 PMPresentationInfo: Scientific presentation by distinguished guest speaker followed by a lively Q&A.
- **Event URL**: https://allevents.in/san-carlos/bioscience-forum-presents-precision-crispr-therapies/100001983851221407
- **Event Categories**: business, nonprofit
- **Interested Audience**: 
  - total_interested_count: 0

## Ticket Details

- **Ticket Price Range**: min: 40, max: 45, currency: USD

## Event venue details

- **city**: San Carlos
- **state**: CA
- **country**: United States
- **location**: The Alexandria at San Carlos
- **lat**: 37.5071201
- **long**: -122.250491
- **full address**: The Alexandria at San Carlos, 835 Industrial Road, San Carlos, United States

## Event gallery

- **Alt text**: BioScience Forum Presents: Precision CRISPR Therapies
  - **Image URL**: https://cdn-az.allevents.in/events5/banners/8a8832576611d4832a74b0ad8b4309f0729f9f03a45be73e3ae856793ac6b6d2-rimg-w1127-h560-dc2f4c5b-gmir.jpg?v=1772153233

## FAQs

- **Q**: When and where is BioScience Forum Presents: Precision CRISPR Therapies being held?
  - **A:** BioScience Forum Presents: Precision CRISPR Therapies takes place on Tue, 31 Mar, 2026 at 05:00 pm to Tue, 31 Mar, 2026 at 07:00 pm at The Alexandria at San Carlos, 835 Industrial Road, San Carlos, United States.
- **Q**: How much do tickets cost for BioScience Forum Presents: Precision CRISPR Therapies?
  - **A:** Ticket prices for BioScience Forum Presents: Precision CRISPR Therapies range from USD 40 to USD 45 depending on the ticket type. Here's a full breakdown of available ticket types:Ticket TypePriceAvailabilityGeneral AdmissionUSD 40AvailableDay of Event AdmissionUSD 45Available
- **Q**: Who is organizing BioScience Forum Presents: Precision CRISPR Therapies?
  - **A:** BioScience Forum Presents: Precision CRISPR Therapies is organized by BioScience Forum.
- **Q**: Who is this event for? Is it right for me?
  - **A:** BioScience Forum Presents: Precision CRISPR Therapies is ideal for professionals, entrepreneurs, startup founders, and networking enthusiasts eager to grow their connections. Whether you're a first-time attendee or a longtime enthusiast in San Carlos, this event is thoughtfully curated to deliver a standout experience worth every moment. If BioScience Forum Presents: Precision CRISPR Therapies sounds like your kind of event, don't wait - spots fill up fast.

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