

# Event Details

- **Event Name**: Lee Kuan Yew Distinguished Visitors Programme - Public Lecture Series
- **Event Start and End Date**: Wed, 04 Feb, 2026 at 10:00 am – Wed, 04 Feb, 2026 at 11:30 am
- **Event Description**: Shooting the Messenger: Antisense Oligonucleotides for Rare-Disease TherapyAbout this EventAbout the speakerProfessor Adrian Krainer, Cold Spring Harbor Laboratory and 2021 Wolf Prize in Medicine LaureateProf Adrian Krainer completed his undergraduate education at Columbia University in 1981, with a B.A. in Biochemistry. He then completed his Ph.D. in Biochemistry at Harvard University in 1986, in the lab of Prof Tom Maniatis. After graduation, he became the first Cold Spring Harbor Fellow, and in 1989 he joined the faculty at Cold Spring Harbor Laboratory. He is currently the St. Giles Foundation Professor at CSHL, and the Deputy Director of Research of the CSHL Cancer Center. He is also a co-founder and Director of Stoke Therapeutics.Adrian's lab at CSHL uses multidisciplinary approaches to elucidate pre-mRNA splicing mechanisms and alternative splicing regulation. An important goal is to apply this knowledge to uncover the roles of defective splicing in genetic diseases and cancer. The lab also uses antisense technology to develop novel therapeutics that target pre-mRNA or mRNA to modulate gene expression post-transcriptionally. One notable application—in collaboration with Ionis Pharmaceuticals and Biogen—was the development of the antisense oligonucleotide nusinersen (Spinraza), which became the first approved drug for spinal muscular atrophy, a severe genetic disease that causes motor-neuron degeneration. Research from the Krainer lab has also implicated splicing alterations in cancer, and his lab is currently pursuing antisense-therapeutic approaches in the context of various cancers.Adrian is a recipient of the Albany Medical Center Prize in Medicine and Biomedical Research, the Wolf Prize in Medicine, the Life Sciences Breakthrough Prize, the RNA Society’s Lifetime Achievement Award, the Reemtsma Foundation International Prize in Translational Neuroscience, the Speiser Award in Pharmaceutical Sciences, the Ross Prize in Molecular Medicine, the Gabbay Award in Biotechnology and Medicine, the Takeda Pharmaceuticals Innovators in Science Senior Scientist Award in Rare Diseases, and the Watanabe Prize in Translational Research. He served as President of the RNA Society, and is a member of the National Academy of Sciences, the National Academy of Medicine, the National Academy of Inventors, and the American Academy of Arts &amp; Sciences.About the topicShooting the Messenger: Antisense Oligonucleotides for Rare-Disease TherapyIn collaboration with Ionis Pharmaceuticals and Biogen, we previously developed nusinersen (Spinraza), an antisense oligonucleotide (ASO) that modulates alternative splicing of SMN2 exon 7, restoring normal levels of functional SMN protein in the context of spinal muscular atrophy (SMA). The long duration of action of CNS-administered ASOs like Spinraza allows infrequent dosing by lumbar puncture, providing a feasible and effective approach to treat neurological disorders. Consequently, many ASOs are being developed against relevant targets in neurology and neuro-oncology, in addition to other targets in the liver and the eye. Splice-switching ASOs, in particular, are highly versatile, because of the pervasiveness of pre-mRNA splicing. They can be designed to upregulate or downregulate the expression of target genes, to change the relative levels of alternatively spliced isoforms, to correct defective splicing, or to bypass frame-disrupting mutations. I will describe selected applications of this powerful technology.Moderated by Moderated by Assoc Prof Polly Chen, Principal Investigator, Cancer Science Institute of Singapore, Department of Anatomy, NUS
- **Event URL**: https://allevents.in/clementi/lee-kuan-yew-distinguished-visitors-programme-public-lecture-series/100001980617962643
- **Event Categories**: sports, art
- **Interested Audience**: 
  - total_interested_count: 0

## Ticket Details

- **Ticket URL**: https://consumer.pxf.io/c/1339408/3151484/39691?partnerpropertyid=1191892&MediaPartnerPropertyId=1191892&svlink=14105511&level=1&u=https%3A%2F%2Fwww.eventbrite.com%2Fe%2Flee-kuan-yew-distinguished-visitors-programme-public-lecture-series-tickets-1980617962643
- **Ticket Price Range**: min: 0, max: 0, currency: SGD

## Event venue details

- **city**: Clementi
- **state**: SG
- **country**: Singapore
- **location**: University Hall, Auditorium
- **lat**: 1.2973013
- **long**: 103.7779042
- **full address**: University Hall, Auditorium, 21 Lower Kent Ridge Road, Clementi, Singapore

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- **organizer**: Office of University Communications (https://allevents.in/org/office-of-university-communications/26882006)

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## FAQs

- **Q**: When is the event happening?
  - **A:** Wed, 04 Feb, 2026 at 10:00 am
- **Q**: Where is the event happening?
  - **A:** University Hall, Auditorium, 21 Lower Kent Ridge Road, Clementi, Singapore
- **Q**: What is the ticket price?
  - **A:** starting from 0 up to 0 SGD
- **Q**: Who is organizing the event?
  - **A:** Office of University Communications
- **Q**: What type of event is this?
  - **A:** sports, art
- **Q**: Where can I find ticket details about Lee Kuan Yew Distinguished Visitors Programme - Public Lecture Series ?
  - **A:** You can find ticket details about this event on AllEvents.

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